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ZAP-70 plays a crucial role in T cell development and function and in CD8 T cell selection. Peripheral T cells from individuals with ZAP-70 deficiency demonstrate defective T cell …
Family and domain databases View all family and domain features for this entry's canonical sequence in the UniParc Feature Viewer.
An important family of positive FtsZ regulatory factors is the FtsZ ring-associated proteins (Zap), ZapA–D. These proteins facilitate Z ring formation by enhancing the formation of protofilament …
Jul 17, 2025 · This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation.
Zeta associated protein (ZAP) 70 deficiency is a rare disease. ZAP70 deficiency results in an autosomal recessive form of severe combined immunodeficiency (SCID) that is characterized …
Here we report the discovery of YacF as a cell division factor belonging to the Zap family of proteins in E. coli that binds the conserved C-terminal tail of FtsZ and bundles FtsZ polymers at …
May 13, 2016 · ZapD is one of several proteins in E. coli that associates with the Z-ring to promote FtsZ bundling and aids in the overall fitness of the division process. In the present study, we …
Conclusion: Newborns with consanguineous parents, positive family history of CID, and low CD8+ T cell counts should be considered for ZAP-70 deficiency screening, since early diagnosis and …
Nov 22, 2021 · Deficiency of ZAP-70 causes a combined immunodeficiency (CID). Affected children present within the first two years of life with a history of recurrent infections, similar to …
Oct 20, 2009 · ZAP70 -related CID is inherited in an autosomal recessive manner. At conception, each sib of an affected individual has a 25% chance of being affected, a 50% chance of being …
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